A spermidine-induced conformational change of long-armed hammerhead ribozymes: ionic requirements for fast cleavage kinetics.

The catalytic activity of the trans cleaving hammerhead ribozyme 2as-Rz12, with long antisense flanks of 128 and 278 nt, was tested under a wide range of different reaction conditions for in vitro cleavage of a 422 nt RNA transcript derived from human immunodeficiency virus type 1 (HIV-1). Depending...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Hammann, C, Hormes, R, Sczakiel, G, Tabler, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1997
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147112/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9365249/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.23.4715
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