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Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans.
The abundance of cis-regulatory polymorphisms in humans suggests that many may have been important in human evolution, but evidence for their role is relatively rare. Four common polymorphisms in the 5' promoter region of factor VII (F7), a coagulation factor, have been shown to affect its tran...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1470926/ https://ncbi.nlm.nih.gov/pubmed/15238535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.103.025726 |
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