Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine.

The synthesis of a diaminopurine PNA monomer, N-[N6-(benzyloxycarbonyl)-2,6-diaminopurine-9-yl] acetyl-N-(2-t-butyloxycarbonylaminoethyl)glycine, and the incorporation of this monomer into PNA oligomers are described. Substitution of adenine by diaminopurine in PNA oligomers increased the T m of dup...

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Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Autores principales:	Haaima, G, Hansen, H F, Christensen, L, Dahl, O, Nielsen, P E
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147079/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9358176/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.22.4639
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