Crystal engineering of analogous and homologous organic compounds: hydrogen bonding patterns in trimethoprim hydrogen phthalate and trimethoprim hydrogen adipate

BACKGROUND: Trimethoprim [2,4-diamino-5-(3',4',5'-trimethoxybenzyl)pyrimidine] is an antifolate drug. It selectively inhibits the bacterial dihydrofolate reductase (DHFR) enzyme. RESULTS: In the crystal structures of trimethoprim (TMP)-hydrogen phthalate (1) and trimethoprim-hydrogen...

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Hlavní autoři: Muthiah, Packianathan Thomas, Francis, Savarimuthu, Rychlewska, Urszula, Warżajtis, Beata
Médium: Artigo
Jazyk:Inglês
Vydáno: Beilstein-Institut 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1470456/
https://ncbi.nlm.nih.gov/pubmed/16603061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1860-5397-2-8
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