Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to the cleavage of BCR-ABL chimeric L6 (b2a2) mRNA.

With the eventual goal of developing a treatment for chronic myelogenous leukemia (CML), attempts have been made to design hammerhead ribozymes that can specifically cleave BCR-ABL fusion mRNA. In the case of L6 BCR-ABL fusion mRNA (b2a2 type; BCR exon 2 is fused to ABL exon 2), which has no effecti...

Volledige beschrijving

Bibliografische gegevens

Gepubliceerd in:	Nucleic Acids Res
Hoofdauteurs:	Kuwabara, T, Warashina, M, Tanabe, T, Tani, K, Asano, S, Taira, K
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Oxford University Press 1997
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146844/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9224607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.15.3074
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!