Overexpression of the inositol phosphatase SopB in human 293 cells stimulates cellular chloride influx and inhibits nuclear mRNA export

SopB is an inositol phosphate phosphatase that is a virulence factor in Salmonella species. We have overexpressed SopB cDNA in a tetracycline-dependent system in human embryonic 293 cells, and used this model system to directly analyze the role of SopB in altering inositol metabolite levels in vivo....

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Feng, Yucheng, Wente, Susan R., Majerus, Philip W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14677/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158563/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.021558098
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