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Glyoxal, a major product of DNA oxidation, induces mutations at G:C sites on a shuttle vector plasmid replicated in mammalian cells.

Glyoxal is a major product of DNA oxidation in which Fenton-type oxygen free radical-forming systems are involved. To determine the mutation spectrum of glyoxal in mammalian cells and to compare the spectrum with those observed in other experimental systems, we analyzed mutations in a bacterial supp...

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Udgivet i:Nucleic Acids Res
Principais autores: Murata-Kamiya, N, Kamiya, H, Kaji, H, Kasai, H
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146688/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9115355/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.10.1897
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