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Structure of a bis-amidinium derivative of Hoechst 33258 complexed to dodecanucleotide d(CGCGAATTCGCG) 2 : the role of hydrogen bonding in minor groove drug-DNA recognition

The crystal structure is reported of a complex between the dodecanucleotide sequence d(CGCGAATTCGCG)2and an analogue of the DNA binding drug Hoechst 33258, in which the piperazine ring has been replaced by an amidinium group and the phenol ring by a phenylamidinium group. The structure has been refi...

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Hlavní autoři: Clark, GR, Boykin, DW, Czarny, A, Neidle, S
Médium: Artigo
Jazyk:Inglês
Vydáno: 1997
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC146637/
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