A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14.

Binding of the signal recognition particle (SRP) to signal sequences during translation leads to an inhibition of polypeptide elongation known as translation arrest. The arrest activity is mediated by a discrete domain comprised of the Alu portion of SRP RNA and a 9 and 14 kDa polypeptide heterodime...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Chang, D Y, Newitt, J A, Hsu, K, Bernstein, H D, Maraia, R J
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 1997
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146575/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9092618/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.6.1117
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