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Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons

Cardiac afferents are sensory neurons that mediate angina, pain that occurs when the heart receives insufficient blood supply for its metabolic demand (ischemia). These neurons display enormous acid-evoked depolarizing currents, and they fire action potentials in response to extracellular acidificat...

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Autori principali: Sutherland, Stephani P., Benson, Christopher J., Adelman, John P., McCleskey, Edwin W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC14653/
https://ncbi.nlm.nih.gov/pubmed/11120882
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