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Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4(+) T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans

The highly pathogenic simian immunodeficiency virus/HIV type 1 (SHIV) chimeric virus SHIV(DH12R) induces a systemic depletion of CD4(+) T lymphocytes in rhesus monkeys during the initial 3–4 weeks of infection. Nonetheless, high levels of viral RNA production continue unabated for an additional 2–5...

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Gespeichert in:
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Igarashi, Tatsuhiko, Brown, Charles R., Endo, Yasuyuki, Buckler-White, Alicia, Plishka, Ronald, Bischofberger, Norbert, Hirsch, Vanessa, Martin, Malcolm A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14644/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11136236/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.021551798
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