Proteomic identification of oncogenic chromosomal translocation partners encoding chimeric anaplastic lymphoma kinase fusion proteins

The anaplastic lymphoma kinase (ALK) on 2p23 is a tyrosine kinase that forms chimeric fusions with numerous translocation partners. We describe a mass spectrometry-based approach for the identification of ALK fusion partners. This approach accurately identified the nucleophosmin (NPM)–ALK fusion pro...

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Autores principales: Elenitoba-Johnson, Kojo S. J., Crockett, David K., Schumacher, Jonathan A., Jenson, Stephen D., Coffin, Cheryl M., Rockwood, Alan L., Lim, Megan S.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2006
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464352/
https://ncbi.nlm.nih.gov/pubmed/16651537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506514103
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