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Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice
Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. Almost all such aneuploidy derives from meiotic errors in females, with increasing maternal age representing a major risk factor. It was recently reported that histones are globally deacetylate...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464342/ https://ncbi.nlm.nih.gov/pubmed/16651529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510946103 |
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