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Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice

Errors in meiotic chromosome segregation are the leading cause of spontaneous abortions and birth defects. Almost all such aneuploidy derives from meiotic errors in females, with increasing maternal age representing a major risk factor. It was recently reported that histones are globally deacetylate...

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Detalhes bibliográficos
Main Authors: Akiyama, Tomohiko, Nagata, Masao, Aoki, Fugaku
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464342/
https://ncbi.nlm.nih.gov/pubmed/16651529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510946103
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