Effects of 15d-PGJ(2) on VEGF-induced angiogenic activities and expression of VEGF receptors in endothelial cells

15-deoxy-(12,14)Δ-prostaglandin-J(2) (15d-PGJ(2)) upregulates expression of vascular endothelial growth factor (VEGF), but may inhibit angiogenesis. We found that 15d-PGJ(2) (1-10 μM) attenuated all VEGF-induced angiogenic activities in human umbilical vein endothelial cells (HUVEC). It blocked almo...

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Detalhes bibliográficos
Main Authors: Funovics, Philip, Brostjan, Christine, Nigisch, Anneliese, Fila, Anna, Grochot, Anna, Mleczko, Katarzyna, Was, Halina, Weigel, Guenter, Dulak, Jozef, Jozkowicz, Alicja
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463995/
https://ncbi.nlm.nih.gov/pubmed/16647637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2006.02.002
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