A multiple-dose pharmacokinetic and pharmacodynamic evaluation of conventional and 19/285 Oros formulations of metoprolol in healthy volunteers

1 Plasma metoprolol concentrations and haemodynamic effects have been measured in six healthy male volunteers during once daily dosing with a 19/285 Oros system and twice daily dosing with 100 mg conventional tablets, on two separate occasions. 2 Plasma drug concentrations throughout the day varied...

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Main Authors: Grainger, S. L., John, V. A., Shotton, P. A., Smith, S. E.
Format: Artigo
Jezik:Inglês
Izdano: 1985
Teme:
Metoprolol Oros Studies
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463773/
https://ncbi.nlm.nih.gov/pubmed/4005129
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