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Stereoselective first-pass metabolism of highly cleared drugs: studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique.

The pharmacokinetics of dextro(+)- and levo(-)-verapamil were studied in five healthy volunteers following oral administration of pseudoracemic verapamil containing equal amounts of unlabelled (-)- and dideuterated (+)-isomer. (+)-verapamil exhibited approximately five times greater Cmax (+): 240 +/...

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Hlavní autoři: Vogelgesang, B, Echizen, H, Schmidt, E, Eichelbaum, M
Médium: Artigo
Jazyk:Inglês
Vydáno: 1984
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1463564/
https://ncbi.nlm.nih.gov/pubmed/6508982
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