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Designer DNA-binding drugs: the crystal structure of a meta-hydroxy analogue of Hoechst 33258 bound to d(CGCGAATTCGCG)2.

An analogue of the DNA binding compound Hoechst 33258, which has the para hydroxyl group altered to be at the meta position, together with the replacement of one benzimidazole group by pyridylimidazole, has been cocrystallized with the dodecanucleotide sequence d(CGCGAATTCGCG)2. The X-ray structure...

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Udgivet i:Nucleic Acids Res
Principais autores: Clark, G R, Squire, C J, Gray, E J, Leupin, W, Neidle, S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1996
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146347/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9017011/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.24.4882
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