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Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA
Mutations in the ATP6 gene of mtDNA (mitochondrial DNA) have been shown to cause several different neurological disorders. The product of this gene is ATPase 6, an essential component of the F(1)F(0)-ATPase. In the present study we show that the function of the F(1)F(0)-ATPase is impaired in lymphoc...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1462703/ https://ncbi.nlm.nih.gov/pubmed/16402916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051748 |
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