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Mapping and conformational characterization of the DNA-binding region of the breast cancer susceptibility protein BRCA1

The breast cancer susceptibility gene, BRCA1, encodes a large nuclear phosphoprotein, the major isoform of which is 1863 amino acids in size. Structure–function studies have been largely restricted to the only two domains identified by homology searches: the RING (really interesting new gene) and BR...

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Detalhes bibliográficos
Main Authors: Naseem, Riffat, Sturdy, Alice, Finch, David, Jowitt, Thomas, Webb, Michelle
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462700/
https://ncbi.nlm.nih.gov/pubmed/16460311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051646
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