Single-nucleotide polymorphisms of the Trypanosoma cruzi MSH2 gene support the existence of three phylogenetic lineages presenting differences in mismatch-repair efficiency.

We have identified single-nucleotide polymorphisms (SNPs) in the mismatch-repair gene TcMSH2 from Trypanosoma cruzi. Phylogenetic inferences based on the SNPs, confirmed by RFLP analysis of 32 strains, showed three distinct haplogroups, denominated A, B, and C. Haplogroups A and C presented strong i...

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Autors principals: Augusto-Pinto, Luiz, Teixeira, Santuza M R, Pena, Sérgio D J, Machado, Carlos Renato
Format: Artigo
Idioma:Inglês
Publicat: 2003
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462559/
https://ncbi.nlm.nih.gov/pubmed/12750325
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