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An alpha-tubulin mutant demonstrates distinguishable functions among the spindle assembly checkpoint genes in Saccharomyces cerevisiae.

Cells expressing a mutant allele of alpha-tubulin, tub1-729, are cold sensitive and arrest as large-budded cells with microtubule defects. The cold sensitivity of tub1-729 is suppressed by extra copies of a subset of the mitotic checkpoint genes BUB1, BUB3, and MPS1, but not MAD1, MAD2, and MAD3. Th...

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Main Authors: Abruzzi, Katharine C, Magendantz, Margaret, Solomon, Frank
格式: Artigo
語言:Inglês
出版: 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1462169/
https://ncbi.nlm.nih.gov/pubmed/12136005
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