Repair of topoisomerase-mediated DNA damage in bacteriophage T4.

Type II topoisomerase inhibitors are used to treat both tumors and bacterial infections. These inhibitors stabilize covalent DNA-topoisomerase cleavage complexes that ultimately cause lethal DNA damage. A functional recombinational repair apparatus decreases sensitivity to these drugs, suggesting th...

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Detalles Bibliográficos
Main Authors: Stohr, B A, Kreuzer, K N
Formato: Artigo
Idioma:Inglês
Publicado: 2001
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1461630/
https://ncbi.nlm.nih.gov/pubmed/11333215
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