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Identification of a novel allele of SIR3 defective in the maintenance, but not the establishment, of silencing in Saccharomyces cerevisiae.

Using a screen for genes that affect telomere function, we isolated sir3-P898R, an allele of SIR3 that reduces telomeric silencing yet does not affect mating. While sir3-P898R mutations cause no detectable mating defect in quantitative assays, they result in synergistic mating defects in combination...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Enomoto, S, Johnston, S D, Berman, J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1461117/
https://ncbi.nlm.nih.gov/pubmed/10835378
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