Oligodeoxynucleotides containing C-7 propyne analogs of 7-deaza-2'-deoxyguanosine and 7-deaza-2'-deoxyadenosine.

The synthesis, hybridization properties and antisense activities of oligodeoxynucleotides (ODNs) containing 7-(1-propynyl)-7-deaza-2'-deoxyguanosine (pdG) and 7-(1-propynyl)-7-deaza-2'-deoxyadenosine (pdA) are described. The suitably protected nucleosides were synthesized and incorporated into ODNs....

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Détails bibliographiques

Publié dans:	Nucleic Acids Res
Auteurs principaux:	Buhr, C A, Wagner, R W, Grant, D, Froehler, B C
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1996
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146038/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8760882/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.15.2974
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