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Interaction of Transported Drugs with the Lipid Bilayer and P-Glycoprotein through a Solvation Exchange Mechanism
Broad substrate specificity of human P-glycoprotein (ABCB1) is an essential feature of multidrug resistance. Transport substrates of P-glycoprotein are mostly hydrophobic and many of them have net positive charge. These compounds partition into the membrane. Utilizing the energy of ATP hydrolysis, P...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Biophysical Society
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1459527/ https://ncbi.nlm.nih.gov/pubmed/16565061 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.077743 |
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