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Molecular and Functional Differences Induced in Thrombospondin-1 by the Single Nucleotide Polymorphism Associated with the Risk of Premature, Familial Myocardial Infarction

A serine (Ser-700) amino acid rather than an asparagine (Asn-700) at residue 700 of thrombospondin-1 has been linked to an increased risk for development of premature, familial heart attacks. We now have identified both functional and structural differences between the Ser-700 and Asn-700 thrombospo...

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Detalhes bibliográficos
Main Authors: Narizhneva, Natalya V., Byers-Ward, Vicky J., Quinn, Martin J., Zidar, Frank J., Plow, Edward F., Topol, Eric J., Byzova, Tatiana V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1459418/
https://ncbi.nlm.nih.gov/pubmed/15007078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M311090200
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