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A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection
Nonribosomal peptide synthetases (NRPSs) and polyketide synthases are large, multidomain enzymes that biosynthesize a number of pharmaceutically important natural products. The recognition of biosynthetic intermediates, displayed via covalent attachment to carrier proteins, by catalytic domains is c...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2006
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1459352/ https://ncbi.nlm.nih.gov/pubmed/16567620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601038103 |
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