Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays

Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and counterpart normal DNA and noting regions where heterozygous alleles in the norma...

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Библиографические подробности
Главные авторы: Beroukhim, Rameen, Lin, Ming, Park, Yuhyun, Hao, Ke, Zhao, Xiaojun, Garraway, Levi A, Fox, Edward A, Hochberg, Ephraim P, Mellinghoff, Ingo K, Hofer, Matthias D, Descazeaud, Aurelien, Rubin, Mark A, Meyerson, Matthew, Wong, Wing Hung, Sellers, William R, Li, Cheng
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2006
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458964/
https://ncbi.nlm.nih.gov/pubmed/16699594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020041
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