Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays

Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and counterpart normal DNA and noting regions where heterozygous alleles in the norma...

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Bibliographic Details
Main Authors: Beroukhim, Rameen, Lin, Ming, Park, Yuhyun, Hao, Ke, Zhao, Xiaojun, Garraway, Levi A, Fox, Edward A, Hochberg, Ephraim P, Mellinghoff, Ingo K, Hofer, Matthias D, Descazeaud, Aurelien, Rubin, Mark A, Meyerson, Matthew, Wong, Wing Hung, Sellers, William R, Li, Cheng
Format: Artigo
Language:Inglês
Published: Public Library of Science 2006
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458964/
https://ncbi.nlm.nih.gov/pubmed/16699594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020041
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