Inferring Loss-of-Heterozygosity from Unpaired Tumors Using High-Density Oligonucleotide SNP Arrays

Loss of heterozygosity (LOH) of chromosomal regions bearing tumor suppressors is a key event in the evolution of epithelial and mesenchymal tumors. Identification of these regions usually relies on genotyping tumor and counterpart normal DNA and noting regions where heterozygous alleles in the norma...

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Main Authors: Beroukhim, Rameen, Lin, Ming, Park, Yuhyun, Hao, Ke, Zhao, Xiaojun, Garraway, Levi A, Fox, Edward A, Hochberg, Ephraim P, Mellinghoff, Ingo K, Hofer, Matthias D, Descazeaud, Aurelien, Rubin, Mark A, Meyerson, Matthew, Wong, Wing Hung, Sellers, William R, Li, Cheng
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458964/
https://ncbi.nlm.nih.gov/pubmed/16699594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020041
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