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Monte Carlo simulations of proton pumps: On the working principles of the biological valve that controls proton pumping in cytochrome c oxidase

Gaining a detailed understanding of the proton-pumping process in cytochrome c oxidase (COX) is one of the challenges of modern biophysics. Recent mutation experiments have highlighted this challenge by showing that a single mutation (the N139D mutation) blocks the overall pumping while continuing t...

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Bibliografiske detaljer
Main Authors: Olsson, Mats H. M., Warshel, Arieh
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458913/
https://ncbi.nlm.nih.gov/pubmed/16614069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510860103
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