Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity

Understanding allostery may serve to both elucidate mechanisms of protein regulation and provide a basis for engineering active mutants. Herein we describe directed evolution applied to the integrin α(L) inserted domain for studying allostery by using a yeast surface display system. Many hot spots f...

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Hlavní autoři: Jin, Moonsoo, Song, Gang, Carman, Christopher V., Kim, Yong-Sung, Astrof, Nathan S., Shimaoka, Motomu, Wittrup, Dane K., Springer, Timothy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2006
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458646/
https://ncbi.nlm.nih.gov/pubmed/16595626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601164103
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