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Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity
Understanding allostery may serve to both elucidate mechanisms of protein regulation and provide a basis for engineering active mutants. Herein we describe directed evolution applied to the integrin α(L) inserted domain for studying allostery by using a yeast surface display system. Many hot spots f...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458646/ https://ncbi.nlm.nih.gov/pubmed/16595626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601164103 |
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