Reduction of the toxicity and mutagenicity of aziridine in mammalian cells harboring the Escherichia coli fpg gene.

Aziridine (ethyleneimine) reacts with DNA in vitro, mainly at the N7 position of guanine and N3 of adenine, then imidazole ring opening of the modified guanine results in formation of formamidopyrimidine (FaPy) residues. The Escherichia coli fpg gene encodes a DNA glycosylase that removes FaPy resid...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Cussac, C, Laval, F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145839/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8649994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.9.1742
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