A secondary drug resistance mutation of TEM-1 β-lactamase that suppresses misfolding and aggregation
In Gram-negative bacteria, TEM-1 β-lactamase provides the major mechanism of plasmid-mediated β-lactam resistance. Natural variants of TEM-1 with increased antibiotic resistance have appeared in response to the use of extended-spectrum β-lactam antibiotics (e.g., ceftazidime) and β-lactamase inhibit...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14582/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11114163/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.011454198 |
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