Synthesis and characterization of 8-methoxy-2'- deoxyadenosine-containing oligonucleotides to probe the syn glycosidic conformation of 2'-deoxyadenosine within DNA.

The synthesis of 8-methoxy-2'-deoxyadenosine (moA) protected at N6 as an N,N-dimethylformamidine derivative and incorporation of the modified nucleoside into oligodeoxynucleotides via the phosphoramidite method are described. UV thermal denaturation studies were conducted on duplexes containing moA:...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Eason, R G, Burkhardt, D M, Phillips, S J, Smith, D P, David, S S
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1996
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145706/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8600457/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/24.5.890
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