Intermediate Mutation Frequencies Favor Evolution of Multidrug Resistance in Escherichia coli

In studying the interplay between mutation frequencies and antibiotic resistance among Escherichia coli natural isolates, we observed that modest modifications of mutation frequency may significantly influence the evolution of antibiotic resistance. The strains having intermediate mutation frequenci...

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Bibliografiske detaljer
Main Authors: Denamur, Erick, Tenaillon, Olivier, Deschamps, Catherine, Skurnik, David, Ronco, Esthel, Gaillard, Jean Louis, Picard, Bertrand, Branger, Catherine, Matic, Ivan
Format: Artigo
Sprog:Inglês
Udgivet: Copyright © 2005 by the Genetics Society of America 2005
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456789/
https://ncbi.nlm.nih.gov/pubmed/15965238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.045526
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