Increased adjuvant efficacy in stimulation of antibody responses after macrophage elimination in vivo.

To investigate whether macrophages influence the efficacy of adjuvants, we locally eliminated lymph node macrophages with dichloromethylene diphosphonate containing-liposomes before primary immunization. After macrophage elimination, animals were immunized with a soluble antigen (TNP-KLH; 2,4,6-trin...

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Autors principals: Leenaars, P P, Savelkoul, H F, Hendriksen, C F, Van Rooijen, N, Claassen, E
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456609/
https://ncbi.nlm.nih.gov/pubmed/9155638
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