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SIZ1/SIZ2 Control of Chromosome Transmission Fidelity Is Mediated by the Sumoylation of Topoisomerase II
The Smt3 (SUMO) protein is conjugated to substrate proteins through a cascade of E1, E2, and E3 enzymes. In budding yeast, the E3 step in sumoylation is largely controlled by Siz1p and Siz2p. Analysis of Siz(−) cells shows that SUMO E3 is required for minichromosome segregation and thus has a positi...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
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Copyright © 2006 by the Genetics Society of America
2006
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456244/ https://ncbi.nlm.nih.gov/pubmed/16204216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.047167 |
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