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Disentangling Linkage Disequilibrium and Linkage From Dense Single-Nucleotide Polymorphism Trio Data

Parent-offspring trios are widely collected for disease gene-mapping studies and are being extensively genotyped as part of the International HapMap Project. With dense maps of markers on trios, the effects of LD and linkage can be separated, allowing estimation of recombination rates in a model-fre...

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Autors principals: Clarke, Geraldine M., Cardon, Lon R.
Format: Artigo
Idioma:Inglês
Publicat: Copyright © 2005 by the Genetics Society of America 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456135/
https://ncbi.nlm.nih.gov/pubmed/16118185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.047431
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