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Disentangling Linkage Disequilibrium and Linkage From Dense Single-Nucleotide Polymorphism Trio Data

Parent-offspring trios are widely collected for disease gene-mapping studies and are being extensively genotyped as part of the International HapMap Project. With dense maps of markers on trios, the effects of LD and linkage can be separated, allowing estimation of recombination rates in a model-fre...

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Main Authors: Clarke, Geraldine M., Cardon, Lon R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Copyright © 2005 by the Genetics Society of America 2005
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456135/
https://ncbi.nlm.nih.gov/pubmed/16118185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.047431
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