Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion

The interaction between integrin lymphocyte function-associated antigen-1 (LFA-1) and its ligand intercellular adhesion molecule-1 (ICAM-1) is critical in immunological and inflammatory reactions but, like other adhesive interactions, is of low affinity. Here, multiple rational design methods were u...

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Hlavní autoři: Song, Gang, Lazar, Greg A., Kortemme, Tanja, Shimaoka, Motomu, Desjarlais, John R., Baker, David, Springer, Timothy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1455478/
https://ncbi.nlm.nih.gov/pubmed/16354667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M510454200
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