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Disruption of matrix metalloproteinase 2 binding to integrin α(v)β(3) by an organic molecule inhibits angiogenesis and tumor growth in vivo
Matrix metalloproteinase 2 (MMP2) can associate with integrin α(v)β(3) on the surface of endothelial cells, thereby promoting vascular invasion. Here, we describe an organic molecule (TSRI265) selected for its ability to bind to integrin α(v)β(3) and block α(v)β(3) interaction with MMP2. Although di...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC14554/ https://ncbi.nlm.nih.gov/pubmed/11134507 |
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