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The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

GCN2 stimulates translation of GCN4 mRNA in amino acid-starved cells by phosphorylating translation initiation factor 2. GCN2 is activated by binding of uncharged tRNA to a domain related to histidyl-tRNA synthetase (HisRS). The HisRS-like region contains two dimerization domains (HisRS-N and HisRS-...

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Hlavní autoři: Qiu, Hongfang, Dong, Jinsheng, Hu, Cuihua, Francklyn, Christopher S., Hinnebusch, Alan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC145529/
https://ncbi.nlm.nih.gov/pubmed/11250908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.6.1425
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