The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

GCN2 stimulates translation of GCN4 mRNA in amino acid-starved cells by phosphorylating translation initiation factor 2. GCN2 is activated by binding of uncharged tRNA to a domain related to histidyl-tRNA synthetase (HisRS). The HisRS-like region contains two dimerization domains (HisRS-N and HisRS-...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Qiu, Hongfang, Dong, Jinsheng, Hu, Cuihua, Francklyn, Christopher S., Hinnebusch, Alan G.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145529/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11250908/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.6.1425
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