Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus

Agonist-dependent desensitization and internalization of G protein-coupled receptors (GPCR) are mediated by the binding of arrestins to phosphorylated receptors. The affinity of arrestins for the phosphorylated GPCR regulates the ability of the internalized receptor to be dephosphorylated and recycl...

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Main Authors: Barak, Larry S., Oakley, Robert H., Laporte, Stéphane A., Caron, Marc G.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC14550/
https://ncbi.nlm.nih.gov/pubmed/11134505
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https://ncbi.nlm.nih.gov/pmc/articles/PMC14550/
https://ncbi.nlm.nih.gov/pubmed/11134505