DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosis

One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotox...

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Main Authors: Durbach, Steven I., Springer, Burkhard, Machowski, Edith E., North, Robert J., Papavinasasundaram, K. G., Colston, M. Jo, Böttger, Erik C., Mizrahi, Valerie
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2003
Ábhair:
Molecular Pathogenesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC145403/
https://ncbi.nlm.nih.gov/pubmed/12540583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.2.997-1000.2003
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