DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosis

One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotox...

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Detalhes bibliográficos
Main Authors: Durbach, Steven I., Springer, Burkhard, Machowski, Edith E., North, Robert J., Papavinasasundaram, K. G., Colston, M. Jo, Böttger, Erik C., Mizrahi, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC145403/
https://ncbi.nlm.nih.gov/pubmed/12540583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.2.997-1000.2003
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