DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosis

One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotox...

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Главные авторы: Durbach, Steven I., Springer, Burkhard, Machowski, Edith E., North, Robert J., Papavinasasundaram, K. G., Colston, M. Jo, Böttger, Erik C., Mizrahi, Valerie
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2003
Предметы:
Molecular Pathogenesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC145403/
https://ncbi.nlm.nih.gov/pubmed/12540583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.2.997-1000.2003
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