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UreR, the Transcriptional Activator of the Proteus mirabilis Urease Gene Cluster, Is Required for Urease Activity and Virulence in Experimental Urinary Tract Infections

Proteus mirabilis, a cause of complicated urinary tract infection, produces urease, an essential virulence factor for this species. UreR, a member of the AraC/XylS family of transcriptional regulators, positively activates expression of the ure gene cluster in the presence of urea. To specifically e...

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Published in:Infect Immun
Main Authors: Dattelbaum, Jonathan D., Lockatell, C. Virginia, Johnson, David E., Mobley, Harry L. T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2003
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC145398/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12540589/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.71.2.1026-1030.2003
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