Src-family kinases mediate an outside-in signal necessary for β2 integrins to achieve full activation and sustain firm adhesion of polymorphonuclear leucocytes tethered on E-selectin

In cell suspensions subjected to high-shear rotatory motion, human PMN (polymorphonuclear cells) adhered to E-selectin-expressing CHO (Chinese-hamster ovary) cells (CHO-E), and formed homotypic aggregates when challenged by E-selectin–IgG fusion protein, by a mechanism that involved β2 integrins. Bo...

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Main Authors: Totani, Licia, Piccoli, Antonio, Manarini, Stefano, Federico, Lorenzo, Pecce, Romina, Martelli, Nicola, Cerletti, Chiara, Piccardoni, Paola, Lowell, Clifford A., Smyth, Susan S., Berton, Giorgio, Evangelista, Virgilio
Formato: Artigo
Idioma:Inglês
Publicado: Portland Press Ltd. 2006
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1449987/
https://ncbi.nlm.nih.gov/pubmed/16433632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051924
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