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Combining Mathematical Models and Statistical Methods to Understand and Predict the Dynamics of Antibiotic-Sensitive Mutants in a Population of Resistant Bacteria During Experimental Evolution

Temporarily discontinuing the use of antibiotics has been proposed as a means to eliminate resistant bacteria by allowing sensitive clones to sweep through the population. In this study, we monitored a tetracycline-sensitive subpopulation that emerged during experimental evolution of E. coli K12 MG1...

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Main Authors: De Gelder, Leen, Ponciano, José M., Abdo, Zaid, Joyce, Paul, Forney, Larry J., Top, Eva M.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1448808/
https://ncbi.nlm.nih.gov/pubmed/15579675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.104.033431
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