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The Negative c-Myc Target Onzin Affects Proliferation and Apoptosis via Its Obligate Interaction with Phospholipid Scramblase I

Onzin, the product of a negatively c-Myc-regulated target gene, is highly expressed in myeloid cells. As a result of its interaction with and activation of Akt1 and Mdm2, onzin down-regulates p53. The apoptotic sensitivity of several cell lines is thus directly related to onzin levels. We have condu...

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Main Authors: Li, Youjun, Rogulski, Kenneth, Zhou, Quansheng, Sims, Peter J., Prochownik, Edward V.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2006
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1447419/
https://ncbi.nlm.nih.gov/pubmed/16611984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.26.9.3401-3413.2006
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