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Inactivating a Cellular Intrinsic Immune Defense Mediated by Daxx Is the Mechanism through Which the Human Cytomegalovirus pp71 Protein Stimulates Viral Immediate-Early Gene Expression

Human cytomegalovirus (HCMV) masterfully evades adaptive and innate immune responses, allowing infection to be maintained and periodically reactivated for the life of the host. Here we show that cells also possess an intrinsic immune defense against HCMV that is disarmed by the virus. In HCMV-infect...

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Hlavní autoři: Saffert, Ryan T., Kalejta, Robert F.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440479/
https://ncbi.nlm.nih.gov/pubmed/16571803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.8.3863-3871.2006
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