Systemic Immunization with an ALVAC-HIV-1/Protein Boost Vaccine Strategy Protects Rhesus Macaques from CD4(+) T-Cell Loss and Reduces both Systemic and Mucosal Simian-Human Immunodeficiency Virus SHIV(KU2) RNA Levels

Transmission of human immunodeficiency virus type 1 (HIV-1) occurs primarily via the mucosal route, suggesting that HIV-1 vaccines may need to elicit mucosal immune responses. Here, we investigated the immunogenicity and relative efficacy of systemic immunization with two human ALVAC-HIV-1 recombina...

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Hauptverfasser: Pal, Ranajit, Venzon, David, Santra, Sampa, Kalyanaraman, Vaniambadi S., Montefiori, David C., Hocker, Lindsey, Hudacik, Lauren, Rose, Nicolas, Nacsa, Janos, Edghill-Smith, Yvette, Moniuszko, Marcin, Hel, Zdeněk, Belyakov, Igor M., Berzofsky, Jay A., Parks, Robyn Washington, Markham, Phillip D., Letvin, Norman L., Tartaglia, Jim, Franchini, Genoveffa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2006
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440474/
https://ncbi.nlm.nih.gov/pubmed/16571790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.8.3732-3742.2006
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